The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers

• Status: Completed
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion (Zyban). We compare cue-induced reactivity to smoking videos in smokers who were successfully treated with Bupropion to smokers who are still smoking. We measured the brain's metabolic activity in response to smoking and neutral cues in Positron Emission Tomography using FDG.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tel-Aviv Sourasky Medical Center
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Cigarette smokers (over 1 pack a day)

• Age 20-65, male-females

Exclusion Criteria:

• Dependence on other substances

• Psychiatric diagnosis

• Neurological disorder

• Obesity

• Young persons

• Pregnant women