The Effects of DHA on Periodontitis

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Collaborators: Harvard Medical School; Harvard Medical School (HMS and HSDM); National Center for Research Resources (NCRR)
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• age >40 years

• >20 natural teeth (excluding third molars)

• no orthodontic appliances

• periodontitis defined as >4 teeth with pocket probing depths >5 mm

Exclusion Criteria:

• pregnancy

• diabetes

• severe chronic diseases

• gastrointestinal bleeding

• uncontrolled chronic diseases

• autoimmune disorders

• conditions requiring antibiotic prophylaxis

• warfarin

• clopidogrel

• antimicrobial therapy within 30 days

• chronic use of non-steroidal anti-inflammatory drugs (other than aspirin)

• omega-3 fatty acid use within 6 months

• loose teeth

• painful teeth

• periodontal abscess

• pocket depths >10 mm in >1 tooth

• periodontal therapy within the past two years

• allergy to aspirin

• allergy to fish oil

• allergy to corn oil

• allergy to soybean oil