The Effects of Dexamethasone Administration on Jaundice Following Liver Resection

• Status: Completed
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators were aiming to evaluate whether dexamethasone administration accelerates the recovery from hepatectomy-related jaundice and decreases the rates of post-hepatectomy liver failure and its safety in the subjects who developed elevated serum total bilirubin.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Zhongshan Hospital
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Patients underwent open hepatectomy for liver tumors

• Preoperative liver function was Child-Pugh A, and the liver shear wave elastography (SWE) < 30 kPa

• Postoperative serum total bilirubin > 2.5 ULN in 7 days after hepatectomy

Exclusion Criteria:

• Patients with hilar cholangiocarcinoma or other disease with obstructive jaundice

• Complicating disease with severe dysfunction in respiratory or circulation system or kidney.

• Patients with contraindication of glucocorticoids, including severe infection, active GI bleeding