The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

• Status: Terminated
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

We propose to test whether intraoperative administration of dexmedetomidine will reduce hemodynamic control in the intra- and post-operative periods and reduces PACU analgesic requirements in patients undergoing carotid endarterectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Benzocaine; Desflurane; Dexmedetomidine; Isoflurane; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• Consenting adult patients (age >50 years) undergoing carotid endarterectomy with general anesthesia.

Exclusion Criteria:

• Receiving another alpha 2-adrenoreceptor agonist;

• Contraindication to dexmedetomidine, including allergy;

• Current hepatic disease (liver function tests > twice upper limit of normal);

• Renal insufficiency, as defined by a creatinine > 2.0 mg/dL;

• Mentally impairment, including dementia or delirium;

• Heart block ;

• Sick sinus syndrome;

• Atrial fibrillation with a low ventricular response (< 50 bpm);

• Absolute or relative hypovolemia;

• Prior stroke;

• Severe left-ventricular dysfunction