The Effects of Dexmedetomidine on Intravenous Anesthetic Requirements for Children Undergoing Dental Procedures

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose to determine the propofol and remifentanil sparing effects of a single dose of dexmedetomidine in the dental population. The investigators plan to do this by performing a blinded study with 4 test groups (3 experimental and 1 control), using BIS monitoring to titrate TIVA infusion to an acceptable depth of anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of British Columbia
• Treatments: Anesthetics; Dexmedetomidine

Criteria

Inclusion Criteria:

• ASA 1-2

• Elective dental surgery

• Planned general anesthesia with TIVA

• Age 2-10 years

Exclusion Criteria:

• General anesthesia with inhalation induction

• Documented seizure disorder

• Cardiac disease

• Cardiac rhythm abnormalities

• Chronic hypertension

• Weight < 5th centile or > 95th centile for age

• Pre-operative administration of anxiolytics (such as benzodiazepines or opioid analgesics)

• Hypersensitivity to dexmedetomidine or any other study medication