The Effects of Dobutamine on Postoperative Cardiac Function in Aortic Valve Replacement

• Status: Suspended
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The use of dobutamine in postoperative hemodynamic treatment is widespread despite seemingly intact contraction of the heart. This study aims to elucidate the efficacy of low-dose dobutamine infusion in patients in the postoperative phase replacement of the aortic valve.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Treatments: Dobutamine

Criteria

Inclusion Criteria:

• 18-90 years

• Left ventricular posterior wall =/>12mm

• Ejection fraction > 45%

• Sinus rhythm

• Eligible for aortic valve replacement

Exclusion Criteria:

• Need for concomitant cardiac bypass operation.

• Moderate or severe insufficiency of the mitral valve

• Active endocarditis

• Insufficient ultrasound window

• Using B-blockers

• Liver insufficiency

• Patients treated with COMT-inhibitors

• Allergy towards dobutamine

• Pregnancy

• Women of fertile age who do not use relevant anti-conception

• Lacking participant consent