The Effects of Enzymes and Flavonoids on Inflammation and Coagulation After Marathon

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of the present study is to investigate changes in inflammatory status and incidence of infection after extreme aerobic physical stress (participation in a marathon). In addition, the impact of marathon running on the hemostasis and muscular state will be evaluated. Changes at the inflammatory, muscular, and rheological level will be related to ingestion of oral hydrolytic enzymes and bioflavonoids.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Technische Universität München
• Treatments: Wobenzym

Criteria

Inclusion Criteria:

• • Healthy male

• Age 20-65 years

• History of at least one successfully finished half marathon

• Intention to participate at the Munich Marathon 2013

• Subject is able to read, understand, and sign a written Informed Consent to participate in the Enzy-MagIC-Study

Exclusion Criteria:

• Known cardiac disease

• Known allergy against the active ingredient of the study medication or pineapple, papaya, or kiwi

• Known severe coagulopathy

• Known lactose intolerance

• Pharmaceutical treatment for diabetes mellitus or arterial hypertension

• Acute or chronic renal failure

• Acute or chronic liver disease

• Acute or chronic infection or inflammatory disease

• Use of medications or supplements influencing immune function

• Musculoskeletal or psychiatric disease

• Neoplasia

• Participation in other interventional trials