The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery
Status:
Completed
Trial end date:
2019-08-31
Target enrollment:
Participant gender:
Summary
Allogeneic blood products transfusions are often necessary to treat perioperative bleeding in
patients undergoing complex scoliosis surgeries. A prospective, randomized trial is designed
to evaluate if the infusion of fibrinogen concentrate may reduce allogeneic blood transfusion
in patients undergoing scoliosis surgery. Eligible patients will be randomly assigned to
treatment group (fibrinogen concentrate infusion) and control group (normal saline infusion),
and functional fibrinogen will be measured to guide the infusion of fibrinogen concentrate.
Perioperative blood loss, intraoperative blood loss, and the amount of perioperative
allogeneic blood transfusion will be compared between the two groups to determine the effect
of fibrinogen concentrate infusion.