The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3

• Status: Terminated
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Gamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body. By lowering the level of another neurotransmitter called dopamine, GABA may have the ability to diminish cocaine cravings in addicts. The purpose of this study is to gather information on the interaction between cocaine and selected GABA enhancing medications in individuals addicted to cocaine. This may lead to future clinical studies using GABA medications to treat cocaine addiction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Pregabalin

Criteria

Inclusion Criteria:

• Meets DSM-IV criteria for cocaine dependence

• History of smoked or intravenous cocaine use on average of at least once a week over a 6 month period

• Positive urine test for cocaine

• No current medical problems

• Normal electrocardiogram

• If female, willing to use contraception throughout the study

Exclusion Criteria:

• Seeking treatment for cocaine dependence

• Current major psychiatric illness, including mood disorder, psychotic disorder, or anxiety disorder

• Current dependence on alcohol or any drugs other than cocaine or nicotine

• History of major medical illness, including liver disease, suspected or known cancer, thrombophlebitis, or other medical conditions that are considered unsafe for study participants by the investigator

• Known allergy to study medications

• Pregnant or breastfeeding