The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

• Status: Not yet recruiting
• Trial end date: 2025-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Adrian Vella

Criteria

Inclusion Criteria:

• We will recruit up to 20 weight-stable, subjects with type 2 diabetes

• BMI ≥ 28 Kg/M2

• Diabetes is managed by diet alone or a combination of oral agents

Exclusion Criteria:

• History of prior upper abdominal surgery e.g. gastric banding, pyloroplasty, vagotomy.

• Active systemic illness or malignancy.

• Symptomatic macrovascular or microvascular disease.

• Contraindications to MRI (e.g. metal implants, claustrophobia).

• Hematocrit < 35%

• TSH < 0.4 or > 5.5.

• Consumption of > 2 alcohol drinks per day or > 14 per week or a positive AUDIT questionnaire.