The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle Ear

• Status: Not yet recruiting
• Trial end date: 2024-03-31
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the improvement in middle ear optical coherence tomography imaging from the topical application of glycerol to the tympanic membrane in normal, opaque and post-operative ears

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nova Scotia Health Authority
• Collaborator: Dalhousie University
• Treatments: Glycerol

Criteria

Inclusion Criteria:

• Thickened tympanic membrane (e.g. due to fibrosis) x10

• Tympanosclerosis of the tympanic membrane x10

• History of middle ear surgery with partial or total ossicular replacement prosthesis and cartilage tympanoplasty x10

• History of cartilage tympanoplasty without prosthesis implantation x10

• Normal tympanic membrane without history of middle ear disease x10

Exclusion Criteria:

• Narrow or stenotic external auditory canal that prevents visualization of the tympanic membrane

• Mobility disorder that prevents patient from remaining still during imaging

• Perforation of the tympanic membrane

• Open sores or infections of the external auditory canal