The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Status:
Completed
Trial end date:
2007-10-10
Target enrollment:
Participant gender:
Summary
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes.
Patients with Turner syndrome are typically short, have abnormal physical features, and lack
the physical changes normally associated with puberty. In addition, some patients with Turner
syndrome have low bone density (osteoporosis) and differences in learning abilities.
This study will research the effects of steroid hormones on patients with Turner syndrome. It
will look closely at how taking steroid hormones effects the patient's rate of growth as well
as the patient's ability to learn. In addition the study will investigate how different
hormones (androgen and estrogen) work when given together as a combination.
All patients asked to participate in this study will receive growth hormone injections.
However, half of the patients will receive an additional sex steroid hormone (oxandrolone) in
the form of a pill. The other half of the patients will receive a placebo or "sugar pill".
This will allow the researchers to determine if the combination of the hormones produces
different results than growth hormone alone.
The study will last approximately 2 years. After 2 years of research the patients may qualify
for an additional 2 years of treatment. Patients may benefit directly from this research with
increased growth and improved ability to learn.
Phase:
Phase 2
Details
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)