The Effects of Inhaled Aclidinium Bromide/Formoterol Fumarate on Inspiratory Pleural Pressures in Smokers
Status:
Completed
Trial end date:
2019-02-01
Target enrollment:
Participant gender:
Summary
This short-term study aims to prove the potential cardio-protective physiological effect of
inhaled aclidinium bromide/formoterol fumarate on inspiratory pleural pressures.
Smoking is associated with gas-trapping (hyperinflation), even in the absence of chronic
obstructive pulmonary disease. Breathing in the presence of gas-trapping requires large
negative inspiratory pleural pressures, which are transmitted to the surface of the heart and
increase cardiac wall stress.
Inhaled aclidinium bromide and formoterol fumarate has been shown to reduce gas-trapping, but
the impact on inspiratory pleural pressures and biomarkers of cardiac stress in smokers is
unknown.
Phase:
Phase 3
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre