The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep
Status:
Completed
Trial end date:
2020-11-30
Target enrollment:
Participant gender:
Summary
Adequate sleep is necessary for physical and mental health of human being. Although surgery
and anesthesia techniques have improved in resent years, postoperative sleep disturbance
remains a challenging problem in surgical procedures1. Postoperative sleep fragmentation and
poor sleep quality can not only result in hyperalgesia and a delay in postoperative
recovery2, lack of sleep after surgery can also bring many potential adverse effects such as
cognitive disorders (such as delusions, delirium), chronic pain, mood disorders, metabolic
disorders, and pro-inflammatory changes3-5. Previous studies have reported that age,
preoperative comorbidity and severity of surgical trauma were independent factors that
associated with postoperative sleep disturbance6,7. Our prior studies have also found that
patients are more likely to experience decreased sleep quality after receiving general
anesthesia, which was characterized by a decrease in each sleep stage8. Propofol and
sevoflurane are commonly used general anesthetics in clinical practice. The choice of
anesthetic may also affect the cognitive outcome after surgery, but the results of clinical
studies have always been contradictory. Some studies report that the cognitive results after
inhalation are worse than those after intravenous anesthesia. And the incidence of dreaming
was significantly higher in the sevoflurane anesthesia group compared to the propofol
group9-11. Another study conduct among infants proved that compared with
propofol-remifentanil, sevoflurane appears to be associated with less sleep disturbances in
the first weeks after surgery12. Based on these conflicts, the aim of the current study was
to compare the effect of propofol vs sevoflurane on early postoperative sleep quality and
complications of patients receiving laparoscopic surgery after general anesthesia.