The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

• Status: Active, not recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements.

The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: Beth Israel Deaconess Medical Center
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Age ≥ 18 years admitted to ICU requiring mechanical ventilation

• Suitable for spontaneous breathing trial

• Candidate to received low dose ketamine by the primary critical care team

Exclusion Criteria:

• Esophageal injury

• Allergic to ketamine

• Known neurodegenerative disorders

• Major neurologic disorders (elevated ICP)