The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Status:
Active, not recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Impairment of airway patency is a common cause of extubation failure and opioids and
hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of
N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and
promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid
and propofol requirements.
The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of
ketamine on breathing and electroencephalography in mechanically ventilated patients.