The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
Justification and Objectives: The hemodynamic response to stimuli of the airways is a common
phenomenon and its control is important to decrease systemic repercussions. The objective of
this study is to compare the effects of intravenous administration of Magnesium Sulphate
versus Lidocaine in the hemodynamics of this reflex after laryngoscopy and tracheal
intubation. Methods: This double blind, randomized, single center, and prospective study
evaluated 56 patients, ASA 1 or 2, aged between 18 and 65 years, scheduled for elective
surgeries under general anesthesia with tracheal intubation. Patients were divided into two
groups. Group M received 30mg/kg of Magnesium Sulphate, and group L 2 mg/kg of Lidocaine
through continuous infusion, immediately before induction of anesthesia. The values for blood
pressure (BP), heart rate (HR) and bispectral index (BIS) were measured in both groups at six
distinct moments related to the administration of the drugs under study.