The Effects of Low Dose Atropine on Choroidal Thickness

• Status: Completed
• Trial end date: 2019-02-08
• Target enrollment: 0
• Participant gender: All

Summary

Atropine eye drops are considered to be an effective form of myopia control in human eyes. However, the mechanism by which it exerts it effects are not fully understood. Thickening of the choroid subsequent to atropine administration may play an important role in the mechanisms by which atropine induces myopia control. Literature also notes that choroidal thickness undergoes diurnal variations, which is a variable that will be controlled in this study in order to examine atropine's effects on different baseline choroidal thicknesses.

The purpose of the proposed study is to characterize better the influence of atropine on choroid thickness. The study aims are to:

1. Determine the effect of low dose concentration of topical atropine (0.1% and 0.01%) on choroid thickness

2. Determine the effect of topical atropine on choroid thickness in relationship to baseline thickness throughout the day and after one week of daily instillation

Hypothesis: Atropine's effect on choroidal thickness will be dependent on the subject's baseline thickness measurements, at a designated time of the day when the choroid is at its thinnest.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: State University of New York College of Optometry
• Treatments: Atropine; Ophthalmic Solutions

Criteria

Inclusion Criteria:

• Aged between 18 - 35 years

• Good general and ocular health

• Soft contact lens wearers to cease lens wear for at least 24 hours

• No previous rigid gas permeable lens wear

• Not taking monoamine oxidase inhibitors (MAOIs) and are not pregnant

Exclusion Criteria:

• History of ocular surgery, including refractive surgery

• Use of ocular medications

• Amblyopia

• Conditions where topical atropine is contraindicated

• Any eye or systemic disease that affect vision or refractive error