The Effects of Low Flow and Normal Flow Desflurane Anesthesia

• Status: Completed
• Trial end date: 2022-03-30
• Target enrollment: 0
• Participant gender: All

Summary

Aging is a physiological process. In the elderly, loss of functional reserve in all organ system, regression in anabolic processes and increase in catabolic processes are observed s (1). The number of geriatric patients is also increasing in our country. Technological developments in anesthesia and surgery technics show that we will provide medical services to more elderly patients over time(2). Cystatin C is excreted only by the kidney (7, 8). Serum cystatin C level is not affected by body muscle mass, age and gender. The half-life is short. Because of all these features, it is thought to be more sensitive than creatinine in evaluating kidney functions (8,9). In this study, it was aimed to compare the effects of low flow and normal flow desflurane anesthesia applied in geriatric patients on postoperative liver and kidney functions and serum cystatin C levels.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yuzuncu Yıl University
• Treatments: Anesthetics; Desflurane

Criteria

Inclusion Criteria:

• Patients with an American Society of Anesthesiologists (ASA) status of class I-III,

• Aged between 65 and 100 years,

• Scheduled to undergo general anesthesia and, the surgeries that will take longer than 1 hour.

Exclusion Criteria:

• ASA class ≥ III patients

• Thorasic surgery

• Neurosurgery

• Cardiorespiratory disease,

• Uncontrolled diabetes mellitus,

• Coagulation disorders,

• Preoperative liver and renal dysfunction,

• History of malignant hyperthermia,

• Using nephrotoxic or hepatotoxic drugs,

• Major bleeding (>1000 cc) is predicted in the operation,

• Chronic alcoholism,

• Patients with drug use or withdrawal symptoms