The Effects of Melatonin Treatment on Bone, Marrow, Sleep and Blood Pressure
Status:
Not yet recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
Melatonin protects your bones while losing fat! This was previously demonstrated by our
group. The mechanisms behind these findings are still elusive, and the aim of the present
study is to assess the mechanisms.
In a double-blinded randomized controlled trial 40 postmenopausal woman are randomized to
receive either 10 mg melatonin or placebo nightly for three months. Changes in gene
expression in marrow cells will be assessed through micro array. Markers of bone metabolism
will be assessed through biochemical markers. Cardiovascular health will be measured by
tonometry and 24h blood pressure.
The results of the study will contribute with important knowledge about the beneficial
effects of melatonin making it an interesting supplement to known treatment regimens against
osteoporosis and overweight.