The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

One of nicotine's effects on the body is at the level of the NMDA receptors in the brain. Memantine is a drug that also affects NMDA receptors, making it a candidate for the treatment of nicotine addiction. The purpose of this study is to evaluate the effectiveness of memantine using a laboratory model of tobacco addiction. The investigators will compare the effects of memantine with bupropion, medication currently used to facilitate smoking cessation.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion; Memantine

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of nicotine dependence with psychological dependence

• Smokes at least 15 cigarettes per day for the three months prior to enrollment

• Currently not seeking treatment for nicotine dependence

• Medically healthy on the basis of physical examination and medical history, vital signs, EKG, and laboratory tests

• Females must use an effective method of contraception for the duration of the study

Exclusion Criteria:

• DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine

• Current Axis I diagnosis or current treatment with psychotropic medications within the three months prior to enrollment

• History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety disorders

• Currently seeking treatment for nicotine disorders

• On parole or probation

• History of seizures or head trauma with loss of consciousness, brain contusion, or fracture

• History of significant recent violent behavior

• Blood pressure greater than 150/90

• History of eating disorders

• History of allergic reaction to any of the study medications

• Pregnant