The Effects of Metformin on Morbidity and Mortality in Elderly Patients
Status:
Recruiting
Trial end date:
2024-04-01
Target enrollment:
Participant gender:
Summary
Elderly patients have an increased susceptibility to burns and a substantial mortality that
has not significantly changed over the last three decades. Elderly burn patients not only
have an augmented response to burn but also express a prolonged hypermetabolic
response.Glucose metabolism with insulin resistance is a hypermetabolic response pathway that
profoundly affects post-burn outcomes. The aim if this study is to determine whether
metformin can improve morbidity and mortality in elderly burn patients. The investigators
hypothesize that metformin will improve clinical outcomes and mortality of elderly burn
patients by alleviating the complex inflammatory and hypermetabolic responses after burn.