The Effects of Minocycline in Humans

• Status: Completed
• Trial end date: 2015-11-05
• Target enrollment: 0
• Participant gender: All

Summary

To determine minocycline's effects on cognitive performance and measures of mood in abstinent cocaine users. Minocycline is a tetracycline derivative antibiotic that also inhibits microglia activation and the release of pro-inflammatory cytokines, chemokines, and nitric oxide (NO) production. Previous animal and human studies suggest that minocycline may have utility as a treatment for cocaine addiction.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Minocycline; Tetracycline

Criteria

Inclusion Criteria:

• Male and females, between the ages of 21 and 50 who fulfill criteria for past cocaine dependence according to DSM-IV criteria;

• No cocaine use for the past 30 days;

• No other current dependence or abuse of other drugs of abuse or alcohol (except cocaine and tobacco);

• No current medical problems and normal ECG;

• For women, not pregnant as determined by pregnancy screening nor breast feeding, and using acceptable birth control methods.

Exclusion Criteria:

• current major psychiatric illnesses including mood, psychotic, or anxiety disorders;

• history of major medical illnesses; including liver diseases, heart disease, or other medical conditions that the physician investigator deems contraindicated for the subject to be in the study

• Current use of over-the-counter or prescription psychoactive drugs (antidepressant, anxiolytics, antipsychotics, mood stabilizers, psychostimulants) or drugs that would be expected to have major interactions with drugs to be tested, e.g., benzodiazepines, codeine, percocet, and other opiate drugs that will interact with methadone.

• Liver function tests (ALT or AST) greater than 3 times normal.

• Allergy to minocycline or other tetracyclines.