The Effects of Nanocurcumin on Treg Cells and Th17 Cells Responses in Ankylosing Spondylitis Patients
Status:
Completed
Trial end date:
2018-01-18
Target enrollment:
Participant gender:
Summary
Ankylosing Spondylitis (AS) is a chronic rheumatic disease that principally affects the
intervertebral and sacroiliac joints. Two major features of AS are inflammation and bone
reformation. Th17 cells as a new subpopulation of CD4+ T cells, are characterized by the
production of pro-inflammatory cytokines. Th17 cells have been implicated in autoimmune
diseases, pathogenesis and diagnosis of several inflammatory diseases, such as AS. Regulatory
T cells (Treg) with suppressive effects on inflammation and autoimmunity have been reported
to implicate in pathology of AS. The Treg /Th17 functional balance is essential for the
prevention of autoimmune and inflammatory diseases by preventing deleterious impairment to
the host and mounting effective immune responses. A group of circulating miRNA in plasma is
found to be the change they can be involved in inflammation or inhibit it. miRNAs have been
shown to play a pivotal role in the pathogenesis of various diseases including autoimmune or
auto-inflammatory diseases.The function and molecular pathways of several key deregulated
miRNAs, are elucidated in AS patients. Curcumin is an active component of turmeric which is a
perennial plant. Curcumin is able to exert anti-atherogenic, anti-cancer and
anti-inflammatory effects. The curcumin induces down-regulation of various inflammatory
cytokines including TNF-α and IL-1. The solubility of curcumin in nanomicelles spherical
water increases to more than 100 thousand times, which significantly enhances the absorption
of curcumin. The aim of the present study was to understand the nano-curcumin effects on
frequency of Treg and Th17 cells, expression levels of their associated transcription factors
and cytokines, secretion levels of their associated cytokines and also related miRNAs
expression levels in peripheral blood of patients with AS and their correlation with the
disease progression.
Phase:
Phase 2
Details
Lead Sponsor:
Stem Cell and Regenerative Medicine Institute, Tabriz, Iran Tabriz University of Medical Sciences