The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS
Status:
Completed
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women of
reproductive age and is a leading cause of infertility due to anovulation. Oral contraceptive
pills (OCPs) are considered as first line medical therapy to regularize menses in woman with
PCOS. However they may worsen the metabolic profile of patients by elevating insulin
resistance which is already deranged in PCOS. As there is higher prevalence of insulin
resistance in Indian women with PCOS, insulin sensitisers like metformin may be more
beneficial. Hence this study is undertaken to compare the combined effect of metformin and
OCPs on the clinical, hormonal, metabolic and ovarian ultrasonographic characteristics in
patients with PCOS and to evaluate whether this combination of drugs is more advantageous
than OCPs or metformin alone in improving the clinical and metabolic profile.