The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding

• Status: Recruiting
• Trial end date: 2026-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital

Criteria

Inclusion Criteria:

• Adults 19 years and older

• Hospitalized in the surgical/medical intensive care unit of the Seoul National University Hospital

• Enteral nutrition

• Patients who consented to this study

• Patients with risk factors for pancreatic exocrine dysfunction

• Shock (Norepinephrine)

• Sepsis (3 rd definition of sepsis)

• Diabetes

• Cardiac arrest

• hyperlactatemia serum lactate > 2 mmol/L)

• Mechanical ventilation

• Continuous renal replacement therapy

Exclusion Criteria:

• chronic pancreatitis

• unresectable pancreatic cancer

• History of pancreatectomy

• Underlying diseases in which the effect of Exocrine pancreatic enzyme administration is difficult to show

• Inflammatory bowel disease

• Short bowel syndrome