The Effects of Probiotics in Atopic Dermatitis

• Status: Withdrawn
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to study the clinical effects of taking probiotics in patients who have moderate to severe atopic dermatitis. There has been several studies showing improvement in the severity of atopic dermatitis after taking probiotics. The mechanism of this improvement is currently unknown. We propose that probiotics improve atopic dermatitis by stimulating, or increasing, the activity of a special type of cell called the T Regulatory cell--which can suppress the activity of allergic disease.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Los Angeles
• Collaborator: Thrasher Research Fund

Criteria

Inclusion Criteria:

• Age between 6 months to 3 years

• Physician diagnosis of moderate to severe atopic dermatitis as defined by the Hanifin and Rajka criteria

• Ability to take enterally commercially available probiotics by powder form added to food or drink

• Ability to undergo venipuncture or dermal puncture (if less than 1 year old)

Exclusion Criteria:

• Prior exposure to probiotics

• Current antibiotic administration

• Known history of chronic medical condition such as congenital heart disease, liver or kidney disease, or immune deficiency

• Absence of T regulatory cell induction by probiotic bacteria on initial laboratory assessment

• Any other condition in which the Investigators involved in the study determine potential subject is unsuitable for the study