The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
One important clinical challenge in older individuals is maintaining mobility in the absence
of pain. Peripheral arterial disease affects up to 12% of adults over 50 and impairs quality
of life due to intermittent claudication causing pain and limiting mobility.
Conventional therapies have only modest effect in improving symptoms. The investigators
hypothesise that angiotensin converting enzyme inhibition (with ramipril), which causes
arterial vasodilation, also improves clinical symptoms in patients with peripheral arterial
disease.