The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Coronary heart disease and stroke are two main causes of human deaths and is directly related to increased levels of plasma lipids.High total cholesterol and low high density lipoprotein cholesterol concentrations are often associated with endothelium dysfunction and inflammation, which can be followed by atherosclerosis.

Rhus coriaria L. (Rhus) with the public name of "Somagh" is a plant species in the anacardiaceae family that is used as a food supplement, spice in Middle East region (Iran, Turkey and Arabic countries).

In a double blind randomized placebo-controlled clinical trial, the investigators want to evaluate the effects of Somagh (Rhus coriaria L.) on serum lipid levels of patients with hyperlipidemia.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences

Criteria

Inclusion Criteria:

• Age: 20-65 years

• Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl

Exclusion Criteria:

• Serum triglyceride > 500 mg/dl

• Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III)

• Diabetes mellitus

• Hypo. or hyperthyroidism

• Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure

• Use of drugs: OCPs, lipid lowering agents, thiazides

• Pregnancy

• Alcoholism

• History of allergic reaction to Somagh