The Effects of Risperidone and Olanzapine on Thinking

• Status: Completed
• Trial end date: 2006-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this research is to find ways to maximize the benefits of antipsychotic medications for cognition.

Hypothesis: Risperidone and olanzapine will show greater benefits than conventional medications on assessments of social cognition, particularly affect perception and social perception.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Collaborator: Janssen, LP
• Treatments: Olanzapine; Risperidone

Criteria

Inclusion Criteria:

• Diagnosed with schizophrenia disorder by a DSM IV.

• Competent to sign informed consent

• No history of poor response to Risperdal and Zyprexa

• No organic brain disease

Exclusion Criteria:

• Mental retardation or any chronic medical illness which results in the patient not being appropriate for a switch to Risperdal or Zyprexa.