The Effects of Salbutamol on Mannitol Induced Cough Responses in Healthy Controls
Status:
Not yet recruiting
Trial end date:
2021-09-30
Target enrollment:
Participant gender:
Summary
The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke
coughing healthy controls with no evidence of bronchoconstriction (PC20>16mg/ml or mannitol
PD15 > 635 mg, or < 10% incremental fall in FEV1 between consecutive mannitol doses) and if
salbutamol can affect this. This is a double-blind, placebo-controlled analysis in healthy
controls assessing the effects of salbutamol on mannitol induced cough.