The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Hypotension and bradycardia are often observed following induction of dexmedetomidine or
propofol sedation.Cardiac preload decrease by sedative agents was often considered as one of
main causes for this hypotension.The investigators hypothesized that hypotension after
induction of sedation is caused by decrease of preload by sedative agents,and passive leg
raising (PLR)test could predict this event.Dexmedetomidine or propofol infusion in patients
with circulatory failure decrease cardiac preload and enhance preload-dependency and fluid
responsiveness.