The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypotension and bradycardia are often observed following induction of dexmedetomidine or propofol sedation.Cardiac preload decrease by sedative agents was often considered as one of main causes for this hypotension.The investigators hypothesized that hypotension after induction of sedation is caused by decrease of preload by sedative agents,and passive leg raising (PLR)test could predict this event.Dexmedetomidine or propofol infusion in patients with circulatory failure decrease cardiac preload and enhance preload-dependency and fluid responsiveness.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southeast University, China
• Treatments: Propofol

Criteria

Inclusion Criteria:

• patients with at least one of the clinical manifestations of acute circulatory failure; patients undergoing dexmedetomidine or propofol infusion

Exclusion Criteria:

• deep venous thrombosis or elastic compression stocking

• an increase in the intra-abdominal pressure confirmed by clinical examination

• serious central nervous system pathology (head trauma, severe dementia, acute stroke, uncontrolled seizures)

• severe liver disease(Child-Pugh class C)

• unstable angina or acute myocardial infarction

• left ventricular ejection fraction less than 30%

• heart rate(HR) less than 50/min, heart block with second- or third degree

• systolic blood pressure (SBP) less than 90 mmHg despite 2 vasopressors infusion continuously before the begin of dexmedetomidine infusion