The Effects of Sedatives on Tobacco Use Disorder

• Status: Recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arkansas
• Treatments: Hypnotics and Sedatives; Ketamine; Midazolam

Criteria

Inclusion Criteria:

• smoke at least 5 cigarettes per day

• smoked at least 2 years

• negative urine drug screen for psychoactive drugs and negative breath alcohol concentration

• live in Little Rock AR or surrounding area

Exclusion Criteria:

• unstable or stable medical condition that would interact with study medication or participation

• serious head trauma or neurological disorder

• hypertension, abnormal ECG or metabolic blood results

• meet criteria for psychosis, schizophrenia, major depressive disorder, or bipolar disorder

• use of psychoactive drugs or medications

• BMI > 40

• among women, pregnancy or breastfeeding