The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery

• Status: Completed
• Trial end date: 2022-12-16
• Target enrollment: 0
• Participant gender: All

Summary

Abstract Anaesthetic support for cardiac surgery significantly influences the course of the intraoperative period and the success of the postoperative period. Total intravenous anaesthesia and inhalation anaesthesia are the traditional methods of anaesthesia in cardiac surgery. However, there are few studies assessing the effectiveness of surgical aggression protection in cardiac surgery.

Objectives: To study the effectiveness of body protection against surgical aggression by TIVA and inhalational anaesthesia in cardiac surgery.

Materials and methods. The examination and treatment data of 89 patients were included in the study. All patients underwent coronary artery bypass grafting, mitral valve replacement/plasty, aortic valve replacement cardiopulmonary bypass conditions.

The patients were divided into 2 groups according to the type of disease: the first (1) group with coronary heart disease. The second (2) group with valvular heart disease. There were 65 patients in the first group and 22 in the second. Both groups were divided into 3 subgroups according to the type of anaesthesia: patients anaesthetised with propofol, with sevoflurane, with isoflurane.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Astana Medical University
• Treatments: Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• • The age is between 40-60 years old;

• Mitral valve insufficiency grade 3-4;

• Aortic valve insufficiency grade 3-4;

• Participants of both sexes will be included in the study;

• Signed informed consent.

Exclusion Criteria:

• • pregnancy (risk to the baby and the mother)

• allergenic patients (anaphylactic shock).

• vulnerable groups.

• current congestive heart failure;

• current unstable angina pectoris;

• preoperative hemodynamic instability, defined as the use of vasopressors;