Overview

The Effects of Sildenafil on Exercise Function and Capacity in Patients With Fontan Circulation

Status:
Completed

Trial end date:
2012-05-24

Target enrollment:
0

Participant gender:
All

Summary

The study will test the hypothesis that a single dose of sildenafil can increase the exercise capacity of pediatric patients with a Fontan Circulation.

Phase:

Phase 4

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Milton S. Hershey Medical Center
Penn State University

Collaborator:

Children's Miracle Network

Treatments:

Sildenafil Citrate

Criteria

Inclusion Criteria:

- Age 6-17 years

- Male or female

- Possess Fontan Circulation

Exclusion Criteria:

- Severe heart failure (New York Heart Ass. functional class IV)

- Evidence of Fontan pathway obstruction

- History of exercise-induced severe arrhythmias

- Pregnancy (known or suspected)

- Orthopedic limitations that prevent ambulation on a treadmill

- Use of nitroglycerin

- Herbal medications