The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients
Status:
Completed
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
Airway inflammation is partly driven by Th17 and Th17-polarizing cytokines that is
steroid-resistant. Statins could suppress IL-17 cytokines in other diseases such as
atherosclerosis and multiple sclerosis in mouse model. The investigators hypothesize that
statins might provide anti-inflammatory benefit of suppressing IL-17 cytokines in COPD
patients.