The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids

• Status: Recruiting
• Trial end date: 2023-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this study is to reduce fasting circulating BCAA concentrations in volunteers using Sodium Phenylbutyrate. In addition, we aim investigate the effect of BCAA lowering on fasting blood glucose levels, insulin sensitivity measures and muscle metabolism.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Nottingham
• Treatments: 4-phenylbutyric acid

Criteria

Inclusion Criteria:

• • Participant is willing and able to give informed consent for participation in the study

• Not currently taking any medications

• Males between the ages of 18 - 60

• BMI ≥ 30 kg·m2

• FBG ≥ 6 mmol/L ≤ 7mmol/L or HbA1c ≥ 42 mmol/mol 48 ≤ mmol/mol

Exclusion Criteria:

• • Specify any diseases/disorders/ conditions that would preclude entry into the study

• Females

• History or current psychiatric illness

• History or current neurological condition (e.g. epilepsy)

• Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)

• A BMI < 30kg·m2

• FBG >7mmol/L/ or HbA1c >48mmol/mol

• Metabolic disease; Active inflammatory bowel disease

• Chronic kidney disease

• Malignancy

• Recent (6 mo) steroid/ hormone therapy

• Clotting dysfunction

• Musculoskeletal/ neurological disorders

• Active cardiovascular disease or recent cardiac event

• Respiratory disease (not including well-controlled asthma)