The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the effect of (1) increased sodium intake and (2) increased potassium intake on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wageningen University
• Collaborator: Top Institute Food and Nutrition

Criteria

Inclusion Criteria:

• (Pre)hypertension, defined as office SBP: 130-159 mmHg;

• No use of antihypertensive, lipid-lowering, anticoagulant or other cardiovascular medication;

• Age at start of the ≥ 40 years;

• Apparently healthy:

• No reported current or previous metabolic diseases

• No history of cardiovascular diseases

• No history of renal, liver or thyroid diseases

• No history of gastrointestinal diseases

• No diabetes mellitus

• Fasting laboratory parameters within normal range: renal function (serum creatinine, ureum), liver function (ALAT, ASAT, ɣ-GT) and serum glucose.

Exclusion Criteria:

• Body mass index > 40 kg/m²;

• Smoking

• Secondary hypertension;

• Weight loss or weight gain of 5 kg or more during the last 2 months;

• Usage of non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study.

• Medical treatment that may affect blood pressure and not able (or willing) to stop taking them;

• Women taking oral contraceptives or estrogen replacement therapy

• Taking nutritional supplements and unwilling to discontinue;

• Women lactating, pregnant or intend to become pregnant during study;

• Reported dietary habits: medically prescribed diet, slimming diet;

• Reported alcohol consumption > 21 units/w (female subjects) or >28 units/w (male subjects);

• Unable or unwilling to consume one meal every workday at the university, or to consume the prescribed study diet for 13 weeks;

• Problems with consuming the supplements or following the study guidelines;

• Unwilling to undergo home or office blood pressure measurements;

• Recent blood donation i.e. 1 month (male subjects) or 2 months (female subjects) prior to the study and planned donation during the study period;

• Reported intense sporting activities > 10 h/w;

• Not agreeing to be informed about unexpected and medically relevant personal test-results

• Participation in another biomedical trial less than 2 months before the start of the study or at the same time;

• No informed consent signed.