The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity
Status:
Completed
Trial end date:
2021-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess whether the diuretic drug spironolactone can prevent
chronic damage to transplanted kidneys caused by the medication that prevents rejection.
Spironolactone prevents the effects of the hormone aldosterone. Aldosterone is suspected of
being involved in the processes leading to chronic rejection of transplanted kidneys. Hence,
by blocking the effects of aldosterone we hope to be able to prevent loss of kidney function
in transplant patients.