The Effects of Tranexamic Acid on Blood Loss During Orthognathic Surgery

• Status: Withdrawn
• Trial end date: 2020-07-06
• Target enrollment: 0
• Participant gender: All

Summary

This study seeks to answer the question: Does a single pre-operative dose of tranexamic acid have a statistically significant reduction in blood loss during orthognathic surgery?

If it does, this drug may begin to be used routinely during orthognathic surgery to reduce blood loss in our patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nick Emanuele
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Patients undergoing either

• Bilateral saggital split osteotomy (lower jaw surgery)

• Lefort 1 osteotomy (upper jaw surgery)

• Combination of BSSO and Lefort

• Patients between with ages of 16-65

• No cardiac comorbidities (hypertension, congenital heart malformation)

• No known coagulopathy

• No regular prescription medication altering normal blood coagulation (NSAIDs, other anticoagulants)

• ASA I and II patients

Exclusion Criteria:

• Patients younger than 16 and older than 40

• Patients with known coagulopathy

• Patients with cardiac comorbidities

• Patients with a family history of bleeding disorders

• Patients who have undergone previous orthognathic surgery

• ASA III patients or higher