The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action

• Status: Not yet recruiting
• Trial end date: 2026-11-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary early lung cancer. The study will enroll approximately 300 volunteers to compare the progression-free or overall survival in patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors between propofol and sevoflurane for the maintenance of anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• eighteen to eighty-year-old

• ASA class I-III patients

• Received elective thoracic surgery for primary lung tumors under general anesthesia

Exclusion Criteria:

• mental disorder

• poor liver function

• pregnant or lactating women

• morbidly obese

• allergy to any of the drugs used in this study

• recurrent tumor or repeat surgery

• biopsy cases

• incomplete outcome-data

• palliative treatment after surgery

• simultaneous treatment of other malignancies

• emergency surgery

• presence of other malignant tumors

• combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine

• diagnosed as benign lung tumor, or other metastatic lung tumor