The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'. Often, individuals continue to complain of cognitive problems such as lack of attention, diminished motivation, and impaired problem-solving. This study looks at whether residual and cognitive symptoms of depression in individuals are affected by the addition of Wellbutrin (bupropion).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mclean Hospital
• Collaborator: National Association for Research on Schizophrenia and Affective Disorders.
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Depression

• SSRI-treated

Exclusion Criteria:

• Bipolar disorder

• Serotonin-norepinephrine reuptake inhibitor (SNRI) or bupropion treatment

• Treatment-resistant depression

• Seizure disorder

• Bulimia or anorexia nervosa

• Pregnancy