The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients

• Status: Completed
• Trial end date: 2020-09-15
• Target enrollment: 0
• Participant gender: All

Summary

Vasoactive intestinal peptide (VIP) is a peptide of 28 amino acid residues that belongs to the glucagon/secretin superfamily of peptides. Along with other neuropeptides, such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP), it is released from the trigeminal afferents and exerts a strong vasodilating activity on the cranial vasculature. Especially, it shares 70% structure with PACAP and acts on the same receptors. But, unlike it, VIP cannot induce a long-lasting vasodilation and has a modest capability to induce migraine attacks. Whether it may induce migraine-like attacks in migraine patients, as a twenty-minute infusion of PACAP, is unknown.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Vasoactive Intestinal Peptide

Criteria

Inclusion Criteria:

• Diagnosis of migraine without aura as according to the International Classification

• Frequency of migraine attacks between one and six attacks within 8 weeks

• Weight: 50-90 kg

• Fertile women should use contraception. Fertile women do not include hysterectomies women or women who are postmenopausal for at least 2 years. Contraception includes either IUD, birth control pills, surgical sterilization of the woman or depot progesterone

Exclusion Criteria:

• Any other type of headache (including > 2 days of tension-type headache per month)

• Headache less than 48 hours before the start of the experiment

• Daily intake of any medicine other than oral contraception

• Pregnant or breastfeeding women

• Clinical signs of Hypertension (systolic blood pressure > 150 mmHg and / or diastolic blood pressure > 100 mmHg) and/or Hypotension (systolic blood pressure < 90 mm Hg and / or diastolic blood pressure < 50 mmHg)

• Cardiovascular disease of all kinds, including cerebrovascular disease

• Anamnestic or clinical signs of mental illness, abuse or smoking