The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis

• Status: Unknown status
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Topical antibiotic therapy in patients with refractory sinusitis has been shown to improve symptoms, quality of life, and mucosal aspect. In pediatrics allergy clinic at Siriraj hospital since 2006 use Gentamicin nasal irrigation for chronic rhinosinusitis.There have been no prospective studies in gentamicin irrigation in chronic rhinosinusitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mahidol University
• Treatments: Gentamicins

Criteria

Inclusion Criteria:

1. Chronic rhinosinusitis and/or recurrent acute/subacute sinusitis patients who were followed in pediatrics allergy clinic at Siriraj hospital between December 4, 2012, and December 3, 2016

Exclusion Criteria:

1. Patients who used antibiotic prophylaxis within within 1 year before and 6 months after started gentamicin nasal irrigation

2. Patients received IVIG within 1 year before and 6 months after started gentamicin nasal irrigation

3. Patients received IT within 1 year before and 6 months after started gentamicin nasal irrigation

4. Patients underwent endoscopic sinus surgery within 1 year before and 6 months after started gentamicin nasal irrigation

5. Patient who have mental retardation

6. Patient who have aminoglycosides hypersensitivity reactions

7. Pregnancy women and Lactation period

8. Patient who have abnormal hearing test before started gentamicin nasal irrigation

9. Patient who have chronic rhinosinusitis with nasal polyp