The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen in Knee Osteoarthritis
Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
Osteoarthritis of knee is common degenerative musculoskeletal diseases. Non-steroidal
antiinflammatory drugs (NSAIDs) are used to decrease pain symptom but someone can not
tolerate its gastrointestinal adverse effects. In vitro studies showed that curcumin had an
inhibitory effect on substances playing an important role in inflammatory pathway. The
mechanisms by which curcumin prevents inflammation are postulated through inhibition of many
cytokines, for example, lipo-oxygenase, cyclo-oxygenase, and phospholipase. Therefore, if
curcumin is effective as NSAIDs with less side effects, it can be an alternative treatment
for those OA knee patients.