The Efficacy and Safety of Using Tranexamic Acid by Different Means to Reduce Blood Loss During Total Knee Replacement
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
We will investigate the efficacy and safety of using tranexamic acid by intravenous,
intra-articular and combinational administration to reduce blood loss during total knee
replacement. We hypothesize a combined intra-articular and single intravenous dose protocol
of tranexamic acid may achieve a higher therapeutic concentration at the intra-articular and
extra-articular bleeding site with little or no systemic absorption and subsequent systemic
side effects.