The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To observe the efficacy and safety of dexmedetomidine sedation on the patients admitted to the pediatric intensive care unit after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Anhui Provincial Children's Hospital
• Treatments: Dexmedetomidine; Fentanyl; Midazolam

Criteria

Inclusion Criteria:

1. written informed consent；

2. pediatric patients admitted to intensive care unit after general anesthesia;

3. expected mechanical ventilation time >6 hours; （4）1 months to 16 years old; -

Exclusion Criteria:

1. congenital heart disease, arrhythmias and heart failure;

2. Alanine transaminase（ALT） and (or) Aspartate aminotransferase（AST） level is more than twice the upper limit of normal;

3. Creatinine and (or) Blood urea nitrogen（BUN） is more than the upper limit of normal;

4. central nervous system disease;

5. spinal analgesia or muscle relaxants is used during PICU;

6. the drug that affects the nerve conduction is used in one month;

7. allergy to the test drug or having other contraindications;

8. participated in other studies 30 days prior to admission of PICU; -