The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure

• Status: Completed
• Trial end date: 2021-01-10
• Target enrollment: 0
• Participant gender: All

Summary

Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to dentate line . The most important factor is hard stool passing with trauma to anal mucosa. But, diarrhea diarrhea has been another important etiology that happen after some conditions like gastroenteritis, laxative over use, during chemotherapy, and ulcerative colitis exacerbation . In these conditions, it seems the change of stool PH maybe the main reason of inflammation and ulcer in acute phase.

The treatment of acute is medical management with change in bowel habits and conservative therapy such as local lubricant, local vasodilator, and warm sitz bath to improve blood supply and wound healing.

This research clinical trial is designed to show the effect of Asacol suppository in the management of acute fissure due to diarrhea. The hypothesis of this research clinical trial has been referred to the cause of acute fissure ulcer because of diarrhea.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Shiraz University of Medical Sciences
• Treatments: Mesalamine

Criteria

Inclusion Criteria:

For age between 18 and 65 years are the presence of acute anal fissure (with symptoms less than 6 weeks) following chronic diarrhea and subsequent fissure.

Exclusion Criteria:

• Recurrent fissure with skin appendage.

• Long history of constipation.

• Use of immunosuppressive drugs or corticosteroids.

• Inflammatory bowel disease such as Crohn's disease and ulcerative colitis.

• Pregnancy.

• Grade 3 and 4 hemorrhoids.

• Neurological disease.

• Obsessive-compulsive disorder.

• Previous history of anal surgery

• Skin diseases such as eczema and psoriasis.

• Sexually transmitted infections, tuberculosis.

• Mucosal prolapse.

• Anal fistula and pelvic radiotherapy.