The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effect of Denosumab in decreasing the periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within a year after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
• Treatments: Denosumab

Criteria

Inclusion Criteria:

• Patients with Knee Osteoarthritis treated with Total Knee Arthroplasty

Exclusion Criteria:

• Patients allergies to Denosumab

• Patients with previous Osteoporosis treatment

• Patients with renal failure

• Patients with previous Bisphosphonate treatment for more than 5 years