Overview

The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis

Status:
Unknown status
Trial end date:
2018-11-22
Target enrollment:
0
Participant gender:
Female
Summary
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. Intrauterine balloon has been used for the prevention of intrauterine adhesions. It has been reported that dried biological amnion graft was used to prevent adhesion after the operation of intrauterine adhesions. Estrogen is also used for postoperative prevention of intrauterine adhesions. Intrauterine balloon can reduce the recurrence of adhesions after operation. Disposable balloon uterine stent，which is an innovative intrauterine balloon，is specially designed to fit into the cavity of the uterus. Does Disposable balloon uterine stent and amniotic products combine estrogen therapy improve clinical outcomes? Therefore, this study was conducted.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beijing Obstetrics and Gynecology Hospital
Treatments:
Dydrogesterone
Estradiol
Estradiol 17 beta-cypionate
Estradiol 3-benzoate
Estradiol valerate
Estrogens
Polyestradiol phosphate
Criteria
Inclusion Criteria:

- age 20-40 years；

- previously diagnostic hysteroscopy confirmed adhesion score >5， according to the
American Fertility Society （AFS）classification of IUA；

- complains of menstruation disorder and reproductive dysfunction；

- informed consent.

Exclusion Criteria:

- premature menopause,

- presence of other intrauterine lesions (e.g. polyps, myoma, septa), and

- presence of severe intercurrent illness (e.g. systemic disease, coagulative disorders,
severe kidney and liver diseases),

- adhesions limited to the lower uterine cavity or the cervical canal.