The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the efficacy of Granulocyte Colony Stimulating Factor(G-CSF) on decreasing adhesion reformation and improving fertility outcomes after hysteroscopic adhesiolysis in patients with moderate to severe intrauterine adhesions.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sir Run Run Shaw Hospital
• Collaborators: Ningbo Women and Children's hospital，zhejiang province,China; Wenzhou people's hospital，zhejiang province,China
• Treatments: Estrogens; Hormones; Lenograstim; Progesterone; Sargramostim

Criteria

Inclusion Criteria:

• Moderate and severe intrauterine adhesion patients(AFS score ≥5)

• age 18-40

• first time receiving hysteroscopic adhesiolysis

• provided COOK balloon as adjuvant adhesion prevention treatment

• accepting randomized trial

Exclusion Criteria:

• Mild adhesion patients

• uterine shape can't be restored in the end of surgery

• abnormal chromosome phenotype

• systemic disease

• no fertility desire

• contradiction of G-CSF injection.